A synopsis of Spider-Man 2
So, in the first film, Peter Parker wanted a bunny -- so his aunt and uncle bought him a bunny. Uncle Ben warned Peter that with a bunny came great responsibility, but he didn't listen. While Peter was auditioning for a part on WWE Raw, the bunny killed Uncle Ben.
In the second film, Peter Parker wanted a puppy -- so Aunt May, Mary Jane, and Harry Osborn pitched in and bought him a puppy for his birthday. The ghost of Uncle Ben warned Peter (again) that with a puppy came great responsibility, but he didn't listen (again). While Peter was hitting on Mary Jane, the puppy tried to blow up New York City, foreclosed on Aunt May's house, and beat up some guy in an alley.
Then the bunny ate the puppy and drowned in the Hudson river.
Now, Harry Osborn wants a puppy.